Born in Bohemia, Mandl emigrated to the United States with her family at age fifteen. She spent 40 years working for philanthropic organizations in Chicago, organizations mainly geared toward helping the Eastern European Jewish immigrants. She co-founded the Baron Hirsch Woman's Club, the Home for Jewish Orphans, and the Home for Jewish Friendless and Working Girls. Her tireless efforts on behalf of working women and for the poor during the outbreaks of tuberculosis earned her honors from the Chicago Jewish community. She had two children.
Sources: Jewish Women's Archive