Listed Alphabetically, by First Year of Service
| Senator | Party-State | Service |
| David Levy Yulee | D-FL | 1845-1851, 1855-1861 |
| Judah Benjamin | Whig-LA | 1853-1861 |
| Benjamin Jonas | D-LA | 1879-1885 |
| Joseph Simon | R-OR | 1898-1903 |
| Isidor Rayner | D-MD | 1905-1912 |
| Simon Guggenheim | R-CO | 1907-1913 |
| Herbert Lehman | D-NY | 1949-1957 |
| Richard Neuberger | D-OR | 1955-1960 |
| Jacob Javits | R-NY | 1957-1981 |
| Ernest Gruening | D-AK | 1959-1969 |
| Abraham Ribicoff | D-CT | 1963-1981 |
| Howard Metzenbaum | D-OH | 1974, 1976-1995 |
| Richard Stone | D-FL | 1975-1980 |
| Edward Zorinsky | D-NE | 1976-1987 |
| Rudolph Boschwitz | R-MN | 1978-1991 |
| Carl Levin | D-MI | 1979-2015 |
| Warren Rudman | R-NH | 1980-1993 |
| Arlen Specter | R/D-PA* | 1981-2011 |
| Frank Lautenberg | D-NJ | 1982-2001, 2003-2013 |
| Jacob (Chic) Hecht | R-NV | 1983-1989 |
| Herb Kohl | D-WI | 1989-2013 |
| Joseph Lieberman | D/I-CT** | 1989-2013 |
| Paul Wellstone | D-MN | 1991-2002 |
| Barbara Boxer | D-CA | 1992-2017 |
| Dianne Feinstein | D-CA | 1992-2023 |
| Russ Feingold | D-WI | 1993-2011 |
| Ron Wyden | D-OR | 1996- |
| Charles Schumer | D-NY | 1999- |
| Norm Coleman | R-MN | 2003-2009 |
| Benjamin Cardin | D-MD | 2007- |
| Bernard Sanders | I-VT | 2007- |
| Michael Bennet# | D-CO | 2009- |
| Al Franken | D-MN | 2009-2017*** |
| Richard Blumenthal | D-CT | 2011- |
| Brian Schatz | D-HI | 2013- |
| Jacky Rosen | D-NV | 2019- |
| Jon Ossoff**** | D-GA | 2021- |
*Changed party affiliation in 2009 from Republican to Democrat
**Elected as an Independent in 2006
***Resigned December 2017
****Won runoff election in January 2021
#Bennet’s mother was Jewish, but he does not affiliate with any religion.
Sources: L. Sandy Maisel and Ira Forman, Eds, Jews in American Politics, (Lanham: Rowman & Littlefield, 2001), United States Senate, and various news sources.